Association of Antidiabetic Medication Targetting ppar-Gamma Agonists: Design, Synthesis & Evaluation

Thiazolidinedione is an important target for Antidiabetic drugs. There is still significant potential for designing new chemical entity with affordable, safe and efficacious Antidiabetic drug. In present study 2-thioxo4-thiazolidinedione derivatives were designed and interaction of these was investigated by docking studies in the binding site of PPARγ using (PDB ID 1FM9) enzyme using Glide v 5.6 (Schrodinger LLC., New York, USA; http://www.schrodinger.com). Among the series of designed compounds seven compounds with good potential were synthesized. Structural confirmation of these compounds was done by FT-IR, 1H-NMR and Mass spectroscopy. The compounds were evaluated for in vitro Antidiabetic activity against PPARγ agonists. The activity of compound RS4 and RS20 was found to be comparable with Pioglitazone. The above study could be very useful for further design and development of new Antidiabetic drug. Keyword: Antidiabetic, Docking, PPARγ agonist, 2-Thioxo-4-thiazolidinedione --------------------------------------------------------------------------------------------------------------------------Date of Submission: 09-09-2017 Date of acceptance: 22-09-2017 -------------------------------------------------------------------------------------------------------------------------------------